Potentiometric Titration of Trace Concentrations of Penicillamine Using Ion Selective Electrodes
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 11 (9) , 721-726
- https://doi.org/10.1080/00032717808059722
Abstract
Penicillamine (PA) has shown promise as a therapeutic agent in the treatment of rheumatoid arthritis (RA), and a sensitive analytical procedure applicable to physiological fluids is needed. PA is a metal chelating agent which forms very strong complexes with heavy metal ions (e.g., Hg2+, Cu2+, Pb2+). This characteristic has been applied to the analytical problem presented. The method developed is based on potentiometric titration of the ligand with a metal ion solution utilizing for endpoint detection an indicator electrode selective for this metal ion. The procedure described used lead (II) as the titrant and a lead (II) selective electrode. Demonstrated precision was ±2.0% when 7.5 μg PA was determined in 50 ml solution.Keywords
This publication has 5 references indexed in Scilit:
- Coulometric titration of penicillins and penicillamine with mercury(II)Analytica Chimica Acta, 1977
- D‐penicillamine in the treatment of rheumatoid arthritisArthritis & Rheumatism, 1977
- Section 3 Assay of penicillamine in blood and urineCurrent Medical Research and Opinion, 1974
- Determination of thiols with a specific-ion electrodeAnalytical Biochemistry, 1971
- Bestimmung von Penicillamin als Penicillaminsäure durch Chromatographie über AnionenaustauscherHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1965