Microarrays: lost in a storm of data?
- 1 June 2001
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 2 (6) , 441-443
- https://doi.org/10.1038/35077582
Abstract
Microarray expression profiling is instrumental to our understanding of the function of the genome. Resolution of functionally relevant expression patterns will require the analysis of large data sets compiled from multiple investigators. For this and other reasons, I argue that it is crucial for array data to be publicly shared in a format as close to the 'raw data' as possible. Issues such as protection of intellectual property, ensuring quality of the data, and the format and timing for sharing array data are also discussed.Keywords
This publication has 15 references indexed in Scilit:
- Basic microarray analysis: grouping and feature reductionTrends in Biotechnology, 2001
- Significance analysis of microarrays applied to the ionizing radiation responseProceedings of the National Academy of Sciences, 2001
- An evaluation of the performance of cDNA microarrays for detecting changes in global mRNA expressionNucleic Acids Research, 2001
- Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detectionProceedings of the National Academy of Sciences, 2000
- Expression Profiling of Neural Cells Reveals Specific Patterns of Ethanol-Responsive Gene ExpressionMolecular Pharmacology, 2000
- Gene Expression in Human Alcoholism: Microarray Analysis of Frontal CortexAlcohol, Clinical and Experimental Research, 2000
- Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizationsProceedings of the National Academy of Sciences, 2000
- Molecular portraits of human breast tumoursNature, 2000
- Functional Discovery via a Compendium of Expression ProfilesCell, 2000
- The Transcriptional Program in the Response of Human Fibroblasts to SerumScience, 1999