Formylation and bromination ortho to the hydroxy-group of 2-carbonylsubstituted phenols in the presence of titanium(VI)chloride
- 1 January 1973
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 340-345
- https://doi.org/10.1039/p19730000340
Abstract
Formylation with dichloromethyl methyl either and titanium(IV)chloride in dichloromethane, and bromination with bromine and titanium(IV)chloride in dichloromethane, of methyl 2,4-dihydroxybenzoate(16), methyl 2-hydroxy-4-methoxybenzoate(17), ethyl 2-hydroxy-4-methoxy-6-methylbenzoate(21), methylbenzoate(24), and 2-hydroxy-4-methoxyacetophenone (25) produce appreciable amounts of 3-substituted products. This selective substitution in the position ortho to the hydroxy-group is discussed in terms of a six-membered ring titanium complex.Keywords
This publication has 0 references indexed in Scilit: