Enhanced Local Production of Complement Components in the Small Intestines of Patients with Crohn's Disease
- 10 May 1990
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 322 (19) , 1345-1349
- https://doi.org/10.1056/nejm199005103221903
Abstract
There is evidence that complement components may be formed locally in inflammatory lesions containing monocytes and macrophages. To investigate the role of complement in Crohn's disease we measured jejunal-fluid concentrations of the complement components C4, C3, and factor B by perfusion of a closed segment of the jejunum in 22 patients with Crohn's disease thought to be limited to the terminal ileum.This publication has 33 references indexed in Scilit:
- The jejunal secretion of histamine is increased in active Crohn's diseaseGastroenterology, 1990
- Deposits of terminal complement complex (TCC) in muscularis mucosae and submucosal vessels in ulcerative colitis and Crohn's disease of the colon.Gut, 1989
- Latent pulmonary involvement in Crohn's disease: biological, functional, bronchoalveolar lavage and scintigraphic studies.Gut, 1986
- An Assessment of the Extent of Antigenic Analogy between Physiologically Bound C3 and C3 Denatured by Sodium Dodecyl SulphateScandinavian Journal of Immunology, 1985
- Oral manifestations of gastrointestinal diseaseDigestive Diseases and Sciences, 1981
- Biosynthesis of the third component of complement (C3) in vitro by monocytes from both normal and homozygous C3-deficient humans.Journal of Clinical Investigation, 1977
- Genetic polymorphism of C4 in man and localisation of a structural C4 locus to the HLA gene complex of chromosome 6Nature, 1976
- Metastatic Crohn's diseaseBritish Journal of Dermatology, 1976
- IMMUNOHISTOCHEMICAL LOCALISATION OF COMPLEMENT IN INTESTINAL MUCOSAThe Lancet, 1974
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970