One-Pot Preparation of 1-Acyl-1-methoxycarbonyloxiranes and 1-Acyl-1-cyanooxiranes from Methyl 3-Hydroxy-2-methylenealkanoates or 3-Aryl-3-hydroxy-2-methylenepropanenitriles
- 1 January 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1990 (09) , 787-789
- https://doi.org/10.1055/s-1990-27016
Abstract
The reaction of sodium hypochlorite with methyl 3-hydroxy-2methylenealkanoates or 3-aryl-3-hydroxy-2-methylenepropanenitriles, dispersed on silica gel, in acetonitrile leads to oxidation of the alcohol function and epoxidation of the methylene group to give 2,2-disubstituted oxiranes in good yield.Keywords
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