Expulsion of Nippostrongylus brasiliensis from the Intestine of Rats: the Role of a Cellular Component Derived from Bone Marrow
- 1 January 1973
- journal article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 45 (5) , 759-766
- https://doi.org/10.1159/000231075
Abstract
Reconstitution of heavily irradiated rats (750 rad whole-body irradiation) with mesenteric lymph node cells from immune donors and bone marrow cells from either immune or normal (non-immune) donors caused the expulsion of transplanted damaged worms of Nippostrongylus brasiliensis. These results show that a third component derived from bone marrow is required for worm expulsion and is additional to the humoral (worm damage by antibody) and cell-mediated components previously defined by the studies of Jones and Ogilvie [1971], Kelly and Dineen [1972a], Keller and Keist [1972] and Dineen et al. [1973b].Keywords
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