Enzymatic and Circulatory Adjustments to Physical Training in Middle‐Aged Men*

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Abstract
Eleven men aged 54–55 years and free of major cardiovascular abnormalitieswere trained on a bicycle ergometer for 25 minutes three times a week for six weeks. Estimated maximal oxygen uptake increased significantly by 18 per cent. Succinic oxidase activity in muscle tissue increased significantly from 21.4 to 36.4 μl · mg protein‐1· min.‐1 (on average 77 per cent) while muscular blood flow during exercise decreased significantly from 42.8 to 31.9 ml · 100 g‐1· min.‐1 (on average 23 per cent). Discontinuation of the training activities resulted in a return of the enzymatic activity to the pretraining values while the muscular blood flow appeared to remain low as long as five months after the training was stopped. Enzymatic adjustment to training appears to explain, at least partly, the haemodynamic changes observed during training.