Reciprocal mutations of highly conserved residues in transmembrane helices 2 and 7 of the α2A-adrenoceptor restore agonist activation of Gi1α
- 31 December 2001
- journal article
- Published by Elsevier in Cellular Signalling
- Vol. 14 (2) , 139-144
- https://doi.org/10.1016/s0898-6568(01)00218-2
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- The Regulator of G Protein Signaling RGS4 Selectively Enhances α2A-Adreoreceptor Stimulation of the GTPase Activity of Go1α and Gi2αPublished by Elsevier ,2000
- Quantitative Analysis of Formyl Peptide Receptor Coupling to Giα1, Giα2, and Giα3Published by Elsevier ,1999
- The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone ReceptorJournal of Biological Chemistry, 1999
- Activation of the β2-Adrenergic Receptor-Gαs Complex Leads to Rapid Depalmitoylation and Inhibition of Repalmitoylation of Both the Receptor and GαsJournal of Biological Chemistry, 1999
- Analysis of agonist function at fusion proteins between the IP prostanoid receptor and cognate, unnatural and chimaeric G-proteinsBiochemical Journal, 1999
- Rescue of Functional Interactions between the α2A-Adrenoreceptor and Acylation-resistant Forms of Gi1α by Expressing the Proteins from Chimeric Open Reading FramesJournal of Biological Chemistry, 1997
- Measurement of agonist-induced guanine nucleotide turnover by the G-protein Gi1α when constrained within an α2A-adrenoceptor-Gi1α fusion proteinBiochemical Journal, 1997
- Effects of Asn318 and Asp87Asn318 mutations on signal transduction by the gonadotropin-releasing hormone receptor and receptor regulation.Endocrinology, 1996
- Related Contribution of Specific Helix 2 and 7 Residues to Conformational Activation of the Serotonin 5-HT2A ReceptorPublished by Elsevier ,1995
- Effects of Asn87 and Asp318 mutations on ligand binding and signal transduction in the rat GnRH receptor.Journal of Endocrinology, 1993