Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891
- 1 January 1989
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 23 (suppl C) , 1-6
- https://doi.org/10.1093/jac/23.suppl_c.1
Abstract
The most efficient routes for the synthesis of FCE 22101, a pencm antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development.Keywords
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