Correlation of Hyperandrogenism with Hyperinsulinism in Polycystic Ovarian Disease*

Publisher Website
Google Scholar
Abstract
Basal plasma total immunoreactive insulin (insulin), androstenedione and testosterone [T] were evaluated in 14 obese women: 8 with polycystic ovarian disease (PCOD) and 6 obese controls. All 3 hormones were significantly elevated (P < 0.02 to P < 0.001) in PCOD patients. A significant correlation among basal levels of plasma insulin, androstenedione and T was demonstrated. The PCOD group had significantly higher levels of glucose at 1, 2 and 3 h, with similar significant increases in plasma insulin levels at 0, 2 and 3 h. A significant correlation was found between plasma insulin response areas and plasma T (P < 0.001) in the control and PCOD patients. Hyperandrogenism correlates with hyperinsulinism.