Reduction of Particulate Air Pollution Lowers the Risk of Heritable Mutations in Mice
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- 14 May 2004
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 304 (5673) , 1008-1010
- https://doi.org/10.1126/science.1095815
Abstract
Urban and industrial air pollution can cause elevated heritable mutation rates in birds and rodents. The relative importance of airborne particulate matter versus gas-phase substances in causing these genetic effects under ambient conditions has been unclear. Here we show that high-efficiency particulate-air (HEPA) filtration of ambient air significantly reduced heritable mutation rates at repetitive DNA loci in laboratory mice housed outdoors near a major highway and two integrated steel mills. These findings implicate exposure to airborne particulate matter as a principal factor contributing to elevated mutation rates in sentinel mice and add to accumulating evidence that air pollution may pose genetic risks to humans and wildlife.Keywords
This publication has 22 references indexed in Scilit:
- Overview of the Reanalysis of the Harvard Six Cities Study and American Cancer Society Study of Particulate Air Pollution and MortalityJournal of Toxicology and Environmental Health, Part A, 2003
- Ionising radiation and mutation induction at mouse minisatellite lociMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2001
- DNA adduct levels and DNA repair polymorphisms in traffic-exposed workers and a general population sampleInternational Journal of Cancer, 2001
- Semen quality and reproductive health of young Czech men exposed to seasonal air pollution.Environmental Health Perspectives, 2000
- Outdoor air pollution, low birth weight, and prematurity.Environmental Health Perspectives, 2000
- A Novel Unstable Mouse VNTR Family Expanded from SINE B1 ElementsGenomics, 1998
- The Relationship of Urgent Hospital Admissions for Respiratory Illnesses to Photochemical Air Pollution Levels in MontrealEnvironmental Research, 1994
- A Tetranucleotide Repeat Mouse Minisatellite Displaying Substantial Somatic Instability during Early Preimplantation DevelopmentGenomics, 1993
- Characterization of a highly unstable mouse minisatellite locus: Evidence for somatic mutation during early developmentGenomics, 1989
- Etration of Submicron Aerosols Through High-efficiency Air FiltersHealth Physics, 1984