The preparation of 5′‐iodo‐125I‐Δ8‐THC; a radioligand for the radioimmunoassay of cannabinoids
- 1 September 1980
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 17 (5) , 681-689
- https://doi.org/10.1002/jlcr.2580170510
Abstract
Nucleophilic exchange of 5′‐iodo‐Δ8‐THC and sodium iodide‐125 afforded 5′‐iodo‐125I‐Δ8THC with a maximum specific activity of 42 Ci/mmole. The specific activity could be increased to at least 100 Ci/mmole by iodide‐125 displacement of the corresponding 5′‐tosylate. A hapten 5′‐carboxy‐14C‐Δ9‐THC, for use in conjunction with this radioligand, was synthesized from 5′‐bromo‐Δ8‐THC.Keywords
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