Peripheral neuropathy, coagulopathy and nodular regenerative hyperplasia of the liver in a patient with multiple serologic auto-antibody activities and IgM B-cell lymphoma

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Abstract
Zuber M, Gherardi R, Defer G, Gaulard P, Divine M, Zafrani ES (Service de Neurologie, Département de Pathologie Tissulaire et Cellulaire and Départment d'Hématologie Clinique, Hôpital Henri Mondor. Créteil. France). Peripheral neuropathy, coagulopathy and nodular regenerative hyperplasia of the liver in a patient with multiple serologic auto‐antibody activities and IgM B‐cell lymphoma. A patient with IgM‐secreting B‐cell lymphoma developed demyelinating peripheral neuropathy, nodular regenerative hyperplasia of the liver, coagulopathy, and terminal miliary lymphomatous spreading. Serologic auto‐antibody activities directed against myelin associated glycoprotein, prothrombinase complex (i.e. lupus anticoagulant) and smooth muscle cells were detected. It is suggested that there is a link between the IgM gammopathy, the immunological abnormalities and the various clinico‐pathological conditions.