PREVENTION OF INTER-HUMAN TRANSMISSION OF RABIES AFTER CORNEA GRAFT

  • 1 January 1981
    • journal article
    • research article
    • Vol. 293  (13) , 689-692
Abstract
Transplantation of a cornea taken from a donor who died of rabies encephalitis to a normal recipient constitutes an extremely serious exposure. Four cases of this type of human-to-human transmission of rabies virus are known. In these 4 cases, rabies in the donor was diagnosed after the recipient developed fatal rabies. The 1st case of this type of exposure where the diagnosis of rabies in the donor could be made on the day following the transplantation thus allowing application, without delay, of prophylactic therapy for the rabies infection in the recipient, is reported. Interferon, anti-rabies Ig and human diploid cell strain inactivated rabies vaccine were administered. No signs or symptoms of rabies appeared and, > 3 mo. after transplantation, the recipient is well and alive.

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