INDUCTION OF OVULATION IN THE DIESTROUS MOUSE BY GONADOTROPINS

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Abstract
THE INDUCTION of ovulation in adult mice by a single injection of chorionic gonadotropin was reported by Burdick and Whitney (1941). Later Burdick et al (1943) developed this into an assay method. Using adult diestrous mice, and administering the hormone in a single subcutaneous injection, they found that 0.75 I.U. of chorionic gonadotropin induced ovulation in some cases within 24 hours, while 1 I.U produced ovulation in 100 per cent of the mice. They proposed a unit based on ovulation in 50 per cent of the animals. Although they did not test either pregnant mare's serum or pituitary extracts in adult diestrous mice, they found that in immature mice, chorionic gonadotropin was 2 to 4 times as effective as pregnant mare's serum when both were standardized in international units.
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