Saliva as a Specimen for Monitoring Compliance But Not for Predicting Plasma Concentrations in Patients With HIV Treated With Indinavir
- 1 August 2000
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 22 (4) , 437-445
- https://doi.org/10.1097/00007691-200008000-00013
Abstract
The presence of the HIV-protease inhibitor indinavir in saliva was analyzed to investigate whether salivary indinavir concentrations are applicable to monitor compliance and/or predict plasma indinavir levels. Fourteen HIV-infected outpatients treated with indinavir and 24 healthy volunteers who ingested a single dose of indinavir were included. Paired plasma and citric-acid-stimulated saliva samples were analyzed by high-performance liquid chromatography (HPLC). Stimulated salivary indinavir concentrations showed a high correlation (r = 0.85, p 25Keywords
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