Resistance Levels and rpoB Gene Mutations among In Vitro-Selected Rifampin-Resistant Mycobacterium tuberculosis Mutants
- 1 August 2006
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 50 (8) , 2860-2862
- https://doi.org/10.1128/aac.00303-06
Abstract
The distribution and resistance levels of 189 in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants of Beijing and other genotypes were determined. Apart from a higher amount of codon 522 point mutations and large deletions, a spread of mutations similar to that reported for clinical isolates was seen. Most mutations were correlated with high-level resistance; a lower level, or a MIC of <16 mg/liter, was associated with codon 522 mutations. Multiple mutations were detected in two Beijing mutants.Keywords
This publication has 31 references indexed in Scilit:
- Comparison of drug resistance genotypes between Beijing and non-Beijing family strains of Mycobacterium tuberculosis in KoreaJournal of Microbiological Methods, 2005
- The occurrence of rare rpoB mutations in rifampicin-resistant clinical Mycobacterium tuberculosis isolates from KuwaitInternational Journal of Antimicrobial Agents, 2005
- Origin and primary dispersal of the Mycobacterium tuberculosis Beijing genotype: Clues from human phylogeographyGenome Research, 2005
- Impact of drug resistance on fitness of Mycobacterium tuberculosis strains of the W-Beijing genotypeFEMS Immunology & Medical Microbiology, 2004
- Use of a high-density DNA probe array for detecting mutations involved in rifampicin resistance in Mycobacterium tuberculosisClinical Microbiology & Infection, 2004
- Drug-Susceptible Mycobacterium tuberculosis Beijing Genotype Does Not Develop Mutation-Conferred Resistance to Rifampin at an Elevated RateJournal of Clinical Microbiology, 2003
- Nosocomial Outbreak of Multidrug-Resistant Tuberculosis Caused by a Strain of Mycobacterium tuberculosis W-Beijing Family in St. Petersburg, RussiaEuropean Journal of Clinical Microbiology & Infectious Diseases, 2002
- rpoB Gene Mutations in Rifampin-Resistant Mycobacterium tuberculosis Identified by Polymerase Chain Reaction Single-Stranded Conformational PolymorphismEmerging Infectious Diseases, 2001
- Frequency of rpoB Mutations Inside and Outside the Cluster I Region in Rifampin-Resistant Clinical Mycobacterium tuberculosis IsolatesJournal of Clinical Microbiology, 2001
- Detection of rifampicin-resistance mutations in Mycobacterium tuberculosisThe Lancet, 1993