Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain
Open Access
- 1 August 2000
- journal article
- research article
- Published by Elsevier
- Vol. 6 (2) , 269-279
- https://doi.org/10.1016/s1097-2765(00)00028-9
Abstract
No abstract availableKeywords
This publication has 24 references indexed in Scilit:
- Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activationThe EMBO Journal, 2000
- tRNA Discrimination at the Binding Step by a Class II Aminoacyl-tRNA SynthetaseBiochemistry, 1999
- Characterization of the Hemin-sensitive Eukaryotic Initiation Factor 2α Kinase from Mouse Nonerythroid CellsJournal of Biological Chemistry, 1998
- cpc-3, the Neurospora crassa Homologue of Yeast GCN2, Encodes a Polypeptide with Juxtaposed eIF2α Kinase and Histidyl-tRNA Synthetase-related Domains Required for General Amino Acid ControlPublished by Elsevier ,1998
- Functional Characterization of the RNA-binding Domain and Motif of the Double-stranded RNA-dependent Protein Kinase DAI (PKR)Journal of Molecular Biology, 1995
- Class II Aminoacyl Transfer Rna Synthetases: Crystal Structure of Yeast Aspartyl-trna Synthetase Complexed with tRNA AspScience, 1991
- Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.Proceedings of the National Academy of Sciences, 1989
- Escherichia coli formylmethionine tRNA: mutations in GGGCCC sequence conserved in anticodon stem of initiator tRNAs affect initiation of protein synthesis and conformation of anticodon loop.Proceedings of the National Academy of Sciences, 1987
- Aminoacyl-transfer RNA populations in mammalian cells. Chromatographic profiles and patterns of codon recognitionBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979
- Aminoacyl-tRNA Synthetases: General Features and Recognition of Transfer RNAsAnnual Review of Biochemistry, 1979