Histiocytic Medullary Reticulosis With Cutaneous Lesions

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Abstract
Histiocytic medullary reticulosis (HMR) is a rare, uniformly fatal, acute disease of the reticuloendothelial system. The disease is associated with fever, purpura, jaundice, hepatosplenomegaly, lymphadenopathy, and pancytopenia. A patient with HMR is described who had multiple, brown-to-violaceous tumors and plaques in the skin. A biopsy taken from a skin lesion showed the unique histologic finding of HMR, ie, phagocytosis of erythrocytes, platelets, and nuclear debris, by large, atypical histiocytes.

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