Effect of Aldosterone and Desoxycorticosterone on Adrenalectomized Dogs.

Publisher Website
Google Scholar
Abstract
The minimum daily dose of aldosterone when administered in 10% alcohol to adrenalectomized dogs is approx. 10 [mu]g/dog/day whereas 250-125 [mu]g/dog/day is required when the free alcohol of DOC is administered. Thus, aldosterone is about 25 times more active than DOC. Submaintenance doses of aldosterone appear to be less efficient in regulating the serum K level than in maintaining a normal level of serum Na. Hyperpotassemia and symptoms of adrenal failure may be present in dogs presenting normal levels of serum Na. A larger dose of aldosterone is required to maintain a normal level of arterial pressure than is necessary to maintain a normal serum electrolyte pattern. It appears that aldosterone possesses certain physiological properties which distinguish it from desoxycorticosterone compounds.

This publication has 2 references indexed in Scilit: