Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins.

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Abstract
The defective acute leukemia viruses avian myeloblastosis virus (AMV) and E26 virus each contain an insertd cellular sequence related to the same highly conserved cellular gene, proto-amv. The oncogenes of these 2 retroviruses differ from this cellular proto-oncogene in gene structure, transcript structure and gene product. The product of the AMV oncogene (myb) is a 48,000 MW protein, p48myb, encoded by a transduced segment (amv) of proto-amv flanked by short helper-virus-derived terminal sequences. The E26 virus oncogene product is a 135,000 MW protein, p135gag-amve-ets, encoded by significant protions of a viral structural gene (gag), sequences related to proto-amv (amve), and additional E26-specific sequences (ets) transduced from cellular proto-ets. Both p48myb and p135gag-amve-ets transforming proteins are located in the nucleus of chicken cells transformed by these viruses. A protein of 110,000 MW which is specifically immunoprecipitated by antisera to amv peptides and may be the product of the normal cellular gene (proto-amv) has been located in the cytoplasm of cells that express proto-amv mRNA.