How the community effect orchestrates muscle differentiation
- 20 December 2002
- Vol. 25 (1) , 13-16
- https://doi.org/10.1002/bies.10221
Abstract
The “community effect” is necessary for tissue differentiation. In the Xenopus muscle paradigm, e‐FGF has been identified as a candidate community factor. Standley et al.1 now show that the community effect, mediated through FGF signalling, continues to be important at later stages of development in the posterior part of the embryo. In this region, the paraxial mesoderm is still undergoing segmentation into somites, which are the site of early skeletal muscle formation. Indeed, somitogenesis, together with the read‐out of the Hox code, which confers anteroposterior positional identity, is regulated by FGF signalling. This raises the question of the co‐ordination between these events and the community effect which orchestrates myogenesis. BioEssays 25:13–16, 2003.Keywords
This publication has 34 references indexed in Scilit:
- FGF Signaling Controls Somite Boundary Position and Regulates Segmentation Clock Control of Spatiotemporal Hox Gene ActivationCell, 2001
- Localized and Transient Transcription of Hox Genes Suggests a Link between Patterning and the Segmentation ClockCell, 2001
- Vertebrate segmentation: is cycling the rule?Current Opinion in Cell Biology, 2000
- Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis.Genes & Development, 1997
- Requirement of the paraxis gene for somite formation and musculoskeletal patterningNature, 1996
- How is myogenesis initiated in the embryo?Trends in Genetics, 1996
- The community effect, dorsalization and mesoderm inductionCurrent Opinion in Genetics & Development, 1993
- Community effects and related phenomena in developmentCell, 1993
- A community effect in muscle developmentCurrent Biology, 1993