DEGENERATION OF OVA IN THE RAT AND RABBIT FOLLOWING ORAL ADMINISTRATION OF l-(P-2-DIETHYLAMINOETHOXYPHENYL)- l-PHENYL-2-P-ANISYLETHENOL1

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Abstract
A non-steroidal compound, MER-25, l-(p-2-diethylaminoethoxyphenyl)-l-phenyl-2-p-anisylethanol, was administered orally to mated female rats during the period of tubal passage of ova. In animals sacrificed and examined on day 3 after mating, the number of ova found in rats that had received higher doses was very small, but the number of degenerated ova found in the tubes was not significantly high, suggesting that degeneration of tubal ova may be very rapid. In animals examined on days 14-16 after mating, there was more degeneration before implantation than had been indicated by the appearance of 3 day ova, showing that physiological disturbances occurred earlier than morphological degeneration. Complete degeneration was observed in rats that had been treated only once, on day 2 or day 3, at 30-60 mg/kg. Rabbits were fed with MER-25 daily for 4 days at 50 mg/kg, or at 100 mg/kg on day 0, or 25 mg/kg on day 1. Forty-one to 59 percent degeneration of ova was observed in these cases.

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