Investigations of Serum Protein Changes in Combat Casualties

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Abstract
Previous studies in the disturbance of protein equilibrium following surgery and injury in man and experimental animals have shown a catabolic phase, or period of negative nitrogen balance, followed by an anabolic phase, or period of positive nitrogen balance.* The serum protein changes during the catabolic phase were described by Cuthbertson and Tompsett4primarily as a loss of albumin and an increase in globulin. However, the procedure used was a salt precipitation technique that did not separate thea1anda2globulin fractions from the albumin. More recently, Hoch-Ligeti, Irvine, and Sprinkle,5using paper-strip electrophoresis, studied the serum protein changes in a group of 45 surgical patients. Their results indicated a significant decrease in the albumin fraction and an increase ina1anda2globulin fractions in 80% of patients within four days following operation. PURPOSE The massive trauma and extensive surgical procedures experienced

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