MicroRNAs in Cancer
Top Cited Papers
- 1 February 2009
- journal article
- review article
- Published by Annual Reviews in Annual Review of Medicine
- Vol. 60 (1) , 167-179
- https://doi.org/10.1146/annurev.med.59.053006.104707
Abstract
MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.Keywords
This publication has 83 references indexed in Scilit:
- miRiad Roles for the miR-17-92 Cluster in Development and DiseaseCell, 2008
- Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA ClustersCell, 2008
- MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon AdenocarcinomaJAMA, 2008
- Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cellsPublished by Elsevier ,2007
- Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes ApoptosisMolecular Cell, 2007
- BIC and miR‐155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomasThe Journal of Pathology, 2005
- MicroRNA expression profiles classify human cancersNature, 2005
- c-Myc-regulated microRNAs modulate E2F1 expressionNature, 2005
- A microRNA polycistron as a potential human oncogeneNature, 2005
- A pancreatic islet-specific microRNA regulates insulin secretionNature, 2004