Alpha-receptor-mediated modulation of 3H-noradrenaline release from rat brain cortex synaptosomes
- 1 June 1978
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 303 (2) , 193-196
- https://doi.org/10.1007/bf00508068
Abstract
The effects of oxymetazoline and noradrenaline (in the presence of desipramine) on the release of 3H-noradrenaline from rat brain cortex synaptosomes were studied using a superfusion technique. Both drugs (at 1μM concentrations) were found to reduce the depolarization-induced (15 mM K+) release of 3H-noradrenaline. The release-modulating effect of noradrenaline was antagonized by phentolamine and yohimbine. The data provide direct evidence for the hypothesis that α-receptors modulating the release of noradrenaline are localized on varicosities of central noradrenergic neurones.Keywords
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