METABOLISM IN VIVO OF BRAIN GALACTOLIPIDS: THE JIMPY MUTANT

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Abstract
Abstract— The incorporation in vivo of [U‐14C]glucose into the galactolipids of the brain of control and Jimpy mutant mice was examined. Over a 24‐h period of incorporation there was no indication of an increased rate of turnover of brain galactolipids in the mutant. The Jimpy mutant was identified at ages prior to and at the inception of myelination (7–10 days post partum) with a coat marker (Tabby). There was similar total radioactivity in galactolipids of the Jimpy at these ages but a reduction to 13 per Cent of control at 13 days and to 6 per cent at 16 days of postnatal age. This devetopmental pattern of galactolipid synthesis in Jimpy brain is not in accord with a primary defect in the biosynthesis of cerebrosides and sulphatides.