Regulation of dynein‐driven microtubule sliding by an axonemal kinase and phosphatase in Chlamydomonas flagella

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Abstract
The following is a summary of physiological and pharmacological studies of the regulation of dynein‐driven microtubule sliding in Chlamydomonas flagella. The experimental basis for the study is described, and data indicating that an axonemal cAMP‐dependent protein kinase can regulate inner arm dynein activity are reviewed. In addition, preliminary data are summarized indicating that an axonemal type 1 phosphatase can also regulate dynein‐drive microtubule sliding velocity. It is predicted that the protein kinase, phosphatase, and an inner dynein arm component form a regulatory complex in the axoneme.