Anticonvulsant Effect of Dilantin Sodium by Intravenous Administration in Mice

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Abstract
Summary 1. Rate of onset and duration of anticonvulsant effect of intravenous Dilantin sodium against electrically-induced tonic-extensor seizures have been investigated in mice. At 15 mg/kg, the anti-convulsant effect of Dilantin reached a peak approximately 30 minutes after injection, and was maintained for 1 1/2 hours; it then began to decline gradually, persisting more than 8 hours. 2. Dilantin, one minute after intravenous injection, was capable of abolishing the tonic-extensor seizures in mice at doses in proportion to the current strengths employed to produce convulsions.

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