KINETICS OF PHARMACOLOGIC RESPONSE TO COCAINE

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 22  (3) , 465-474
Abstract
Cocaine plasma concentration-response-time data of human subjects obtained from the literature were analyzed by pharmacokinetic methods. The plasma concentration-time data yielded an elimination half-life of approximately 1 h and suggested that only about 20% of an oral dose of cocaine was absorbed intact into the systemic circulation. Response, as assessed by a relative high rating scale, declined linearly with time. The rate of decline of response was 0.0221 high/min. The rate of decline of response was a function of the apparent 1st-order elimination rate constant (K) of the drug and the slope of the response-log plasma concentration curve (m). A value for m of 4.2 high was calculated from the response-time data which agreed well with a value of 3.9 high for m determined from the slope of the response-log plasma concentration curve.

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