A Method for Evaluating the Hemostatic Effect of Various Agents in Thrombocytopenic Rats and Mice
Open Access
- 1 March 1960
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 15 (3) , 388-394
- https://doi.org/10.1182/blood.v15.3.388.388
Abstract
A simple method for measuring the control of blood loss in thrombocytopenic rats and mice is described. The administration of lyophilized platelets, brain phospholipid extract and soya bean extract failed to correct the blood loss in the thrombocytopenic animal. The results obtained with this method have failed to support the effectiveness of "platelet substitutes" in in vivo systems and reaffirm the requisites of viability and recirculation for platelet transfusions.Keywords
This publication has 2 references indexed in Scilit:
- PHOSPHATIDES AS PLATELET SUBSTITUTES IN BLOOD COAGULATION*Annals of the New York Academy of Sciences, 1958
- A FAMILIAL HEMORRHAGIC TRAIT ASSOCIATED WITH A DEFICIENCY OF A CLOT-PROMOTING FRACTION OF PLASMA 1Journal of Clinical Investigation, 1955