FORCED SPINAL DRAINAGE IN ITS RELATION TO INFECTIONS OF THE CENTRAL NERVOUS SYSTEM
- 3 September 1932
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 99 (10) , 826-831
- https://doi.org/10.1001/jama.1932.02740620036008
Abstract
In 1919, Weed and McKibbon1demonstrated that the intravenious injection of a hypotonic solution increased the intracranial pressure. In 1923 and 1924, Weed2found that the intravenous injection of a hypotonic solution in animals caused a hydrosis of the central nervous system. The essential changes were a hydrosis of the cells in the choroid plexus, a collection of fluid in the perineural spaces, a dilatation of the perivascular channels that lead into the subarachnoid space and an increased intracranial pressure. In 1928, Kubie3demonstrated that if a hypotonic solution is injected into the blood stream of animals there is a marked increase in intracranial pressure and a striking hydration of the central nervous system. If, however, a needle is introduced into the subarachnoid space and the increased fluid is allowed to drain, there is no rise in intracranial pressure and no hydrosis of the central nervous systemKeywords
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