Potassium Loss from Human Erythrocytes Exposed to Amphotericin B
- 1 January 1965
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 118 (1) , 297-300
- https://doi.org/10.3181/00379727-118-29825
Abstract
Summary When fresh human erythrocytes are suspended in buffered solution containing amphotericin B, potassium loss begins within 3 minutes and continues for some time before appreciable hemolysis occurs. The kinetics of the potassium loss indicate that amphotericin B markedly increases cell membrane permeability. The concentration difference of potassium ion across the cell membrane decays at a rate which depends on the dose of amphotericin B.Keywords
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