Studies in Purine Metabolism

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Abstract
The chemical nuclear-plasmic ratio of the liver and of skeletal muscle of dogs has been determined, under various conditions of alimentation. The total N and purine contents of the liver are respectively 43 and 47% higher in dogs fed with meat than those fed on carbohydrates. The nuclear-plasmic ratio of liver tissue in meat-fed, dogs is almost the same as on a carbohydrate diet, indicating that a liberal protein diet does not lead to the formation of specific deposit protein. The content of solid substance is 14% higher in skeletal muscle of dogs fed on a meat than on a carbohydrate diet, pointing to a certain dilution of the tissues in the latter case. The total N and purine contents of skeletal muscle are respectively 35 and 49% higher in dogs fed with meat than those fed on carbohydrates. The nuclear-plasmic ratio of skeletal muscle in meat-fed dogs is slightly higher than that encountered in carbohydrate feeding; hence specific reserve protein is not laid down in the muscles as a result of exclusive protein feeding. In starvation, the nuclear-plasmic ratio of the liver is 10% above normal, pointing to the possible presence of specific reserve protein in this organ. Under similar conditions, the nuclear-plasmic ratio of skeletal muscle is unchanged, indicating that deposit protein is absent from this tissue.

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