Constituents of Domestic Citrus Plants. Part XXIII. Citbismine-A, -B and -C, New Binary Acridone Alkaloids from Citrus Plants.

1 January 1995

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 43 (8) , 1340-1345
https://doi.org/10.1248/cpb.43.1340

Abstract

Three novel dimeric acridone alkaloids named citbismine-A (1), -B (3) and -C (5) have been isolated from the roots of Marsh grapefruit (Citrus paradisi) and Hirado-buntan (C. grandis). The structure of citbismine-A was elucidated as 1 by spectroscopic studies and single crystal X-ray analysis. Structure assignments of citbismine-B (3) and -C (5) were based on spectroscopic data including two dimensional (2D)-NMR (correlation spectroscopy (COSY) and heteronuclear multiple bond correlation (HMBC)) experiments. The common structural characteristic is the presence of a C-C bond between the aromatic ring and the dihydrofuran ring of each acridone nucleus.

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