Effects of Cannabis Sativa and Chlorpromazine on Mice as Measured by Two Methods Used for Evaluation of Tranquilizing Agents

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Abstract
An extract of Cannabis sativa, pyrahexyl, a synthetic tetrahydrocan-nabinol, and chlorpromazine was tested for their abilities to suppress the isolation-induced aggressive behavior and the d-amphetamine toxicity of mice. The 3 substances were active in suppressing the aggressiveness of mice, being their ED50 of 2.5,5.4 and 4.2mg/kg, respectively. Cannabis extract, however, was much less efficient than clorpromazine in protecting mice against d-amphetamine toxiclty. The seemingly tranquilizing property of Cannabis as revealed by the aggressiveness method, and the failure to detect such a property by the d-amphetamine toxiclty method are discussed In the light of the factors that interfere with the performance of these tests for assay of tranquilizing agents.

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