Studies on Human Placental Thromboplastin in Vitro and in Vivo

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Abstract
Human placental thromboplastic substances in small doses in vitro caused rapid clotting of hemophilic blood. The substances are waxy, whitish, water-soluble and contain Ca and P. The protein thromboplastin inj. into dogs shortened coag. time, except in large doses. It hardly affected the blood pressure, but in combination with nembutal caused shock in 2 dogs. It was an excellent local hemostatic in dogs. 0.1 ml. coagulated 1 ml. of drawn blood in less than 10 secs. It can be used instead of thrombin in various clinical applications.