Metabolism of Very Low Density Lipoproteins in Hyperlipidaemia: Studies of Apolipoprotein B Kinetics in Man

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Abstract
The metabolism of very low density lipoprotein-B (VLDL-B) peptide was studied in 19 subjects with endogenous hypertriglyceridemia (Types V, IV and IIb), 3 patients with heterozygous familial hyperbetalipoproteinemia (Type IIa) and 8 healthy subjects by reinjecting autologous radioiodinated VLDL. The kinetics of VLDL-B peptide were followed. The mean turnover rate of VLDL-B peptide was significantly higher in the hypertriglyceridemic group than in the control group, but a considerable overlap in turnover rate was found between these groups. The patients with heterozygous familial hyperbetalipoproteinemia had a normal turnover rate of VLDL-B peptide. A significant positive correlation was found between the turnover rate of VLDL-B peptide and VLDL-triglyceride concentration in the whole series. The underlying defect in endogenous hypertriglyceridemia is heterogeneous. Overproduction of VLDL is a major determining factor in some patients; a reduced clearance is the determining factor in others.

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