Analgesic plasma concentrations of morphine in children with terminal malignancy receiving a continuous subcutaneous infusion of morphine sulfate to control severe pain

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Abstract
Children (3) with terminal malignancy received a continuous s.c. infusion of morphine sulfate for the control of severe pain, the morphine dose being adjusted until the patient and/or parent reported complete freedom from pain. Analgesic plasma morphine concentrations at the steady state in these patients ranged from 12.9-57 ng/ml (median 19.6 ng/ml) while receiving morphine doses of 0.45-2.0 mg/h (0.034-0.06 mg/kg per h). One patient, who received morphine 2 mg/h for 12 days demonstrated a 2-fold variation in steady-state plasma concentration during this period.

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