Analysis for Procainamide and N-Acetyl Procainamide in Plasma or Serum by High-Performance Liquid Chromatography
- 1 April 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 23 (4) , 705-708
- https://doi.org/10.1093/clinchem/23.4.705
Abstract
A high-performance liquid chromatographic method is presented for simultaneous analysis for procainamide and N-acetyl procainamide in plasma or serum. The procedure involves internal-standard addition, organic extraction, and separation on a reversed-phase column. The detection limit for procainamide is 0.1 mg/liter and the calibration plot is linear to at least 30 mg/liter. Comparison with a colorimetric assay for procainamide gave a correlation coefficient of 0.989. We checked for interference by a large series of appropriate drugs, and found none, nor did icteric or lipemic sera present problemsThis publication has 2 references indexed in Scilit:
- A new fluorimetric method for procaineamideClinica Chimica Acta; International Journal of Clinical Chemistry, 1976
- Plasma Concentration of Procainamide and Prevalence of Exertional ArrhythmiasAnnals of Internal Medicine, 1974