Effectiveness of mezlocillin in female genital tract infections

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Abstract
One hundred and twenty-six patients with female genital tract infections were treated with intravenous mezlocillin (16 g/day) in a prospective, multicentre, clinical trial. Clindamycin (2 g/day) was added if patients failed to improve within 48 h of mezlocillin therapy. Cure was noted in 84.3%, improvement in 4.8%, and failure in 7.9%. Using the same basic protocol, but with the addition of randomization and blinding, mezlocillin and ampicillin (8 g/day) were compared in 48 and 51 postpartum patients, respectively. No significant differences between mezlocillin and ampicillin treated patients were demonstrable. Side-effects were minimal and insignificant. We conclude that mezlocillin is an effective drug for the treatment of female genital tract infections and that mezlocillin and ampicillin are equally effective in the treatment of postpartum genital tract infections.

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