T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.

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Abstract
To examining more closely the interaction between T and B lymphocytes, an in vitro [murine] T lymphocyte-dependent B lymphocyte proliferation assay was developed. B lymphocyte proliferation in response to antigen depended on the presence of primed T lymphocytes; the B lymphocytes could be derived from nonprimed animals. Apparently these B cells were nonspecifically recruited to proliferate. This nonspecific recruitment was Ir-gene restricted in that B lymphocytes from B10.S mice, which are genetic nonresponders to the polymer Glu60-Ala30-Tyr10 (GAT), could not be stimulated by GAT-primed (responder .times. nonresponder)F1 T cells. The apparent lack of antigen specificity to Ir gene-restricted T-B interaction may have important implications in our understanding of the recognition unit(s) on T lymphocytes.