Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.
Open Access
- 1 November 1985
- journal article
- research article
- Published by Springer Nature in The EMBO Journal
- Vol. 4 (11) , 2861-2867
- https://doi.org/10.1002/j.1460-2075.1985.tb04015.x
Abstract
Four potentially productive and two non‐productive VDJ gene segments were isolated from the DNA of mouse B‐lymphocytes which had been polyclonally activated by bacterial lipopolysaccharide (LPS). Three VDJ regions exhibit VH genes which stem from two novel VH gene families. The complexity of these families is 5‐9 genes. One of the non‐productive VDJ regions exhibits a D segment which may have been generated by joining of two DSP2 segments. Both non‐productive VDJ regions appear to contain rearranged pseudo VH genes. Three potential somatic mutations distributed over two productive VDJ regions are observed.This publication has 28 references indexed in Scilit:
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