Mycophenolic acid is produced during balanced growth of Penicillium brevicompactum
- 1 January 1977
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Microbiology
- Vol. 23 (1) , 20-27
- https://doi.org/10.1139/m77-003
Abstract
When Penicillium brevicompactum is grown on Czapek Dox medium in the surface or sub merged mode as batch or continuous-flow cultures, mycophenolic acid is produced. Unlike the classical secondary metabolic system, 6-methylsalicylic acid production by P. patulum, mycophenolic acid is formed independently of dilution rate in a flow system. Discounting the possibility that strains of P. brevicompactum that produce mycophenolic acid are mutants defective in the control of secondary metabolite biosynthesis, we conclude that mycophenolic acid production is not regulated as part of a non-vegetative genome. An invertase (EC 3.2.1.26) activity has been encountered in both P. brevicompactum and P. patulum.This publication has 6 references indexed in Scilit:
- A combined radiogas chromatograph/mass spectrometer detects intermediates in mycophenollc acid biosynthesisAnalytical Biochemistry, 1976
- Biosynthesis of Secondary Metabolites: Roles of Trace MetalsPublished by Elsevier ,1969
- A theory of the mode of growth of fungi in the form of pellets in submerged cultureProceedings of the Royal Society of London. B. Biological Sciences, 1966
- METABOLIC DEVELOPMENT AND SECONDARY BIOSYNTHESIS IN PENICILLIUM URTICAECanadian Journal of Microbiology, 1965
- BIOSYNTHESIS OF ITACONIC ACID IN ASPERGILLUS-TERREUS .2. EARLY STAGES IN GLUCOSE DISSIMILATION AND THE ROLE OF CITRATE1957
- Studies in the biochemistry of micro-organismsBiochemical Journal, 1933