Abstract
Topics discussed in this review were: brain peptides controlling adenohypophyseal functions; purification, isolation and characterization of thyrotropin releasing factor [TRF], luteinizing hormone releasing factor [LRF] and somatostatin; endorphins as opiate-like peptides of brain or pituitary origin; experimental and clinical [human and animals] studies with TRF and LRF; biological studies with the endorphins; endocrine and paracrine secretions of the brain such as hormones and cybernins.