Renal handling of homologous and heterologous insulin in the isolated perfused rat kidney
- 1 May 1982
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 393 (3) , 227-231
- https://doi.org/10.1007/bf00584074
Abstract
Renal handling of pig-and rat-insulin was studied in the isolated perfused rat kidney. Metabolic clearance rates of both pig- and rat-insulin excceded GFR. Peritubular uptake of pig-insulin accounted for 13%, of rat-insulin for 31% of the total metabolic clearance. The nonfiltering kidney does not remove insulin from the peritubular circulation. Metabolic clearance rates of pig- and rat-insulin are directly related to GFR. The filtration process seems to be necessary for the uptake of insulin at the peritubular site.This publication has 33 references indexed in Scilit:
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