Crystal structure of a yeast TFIIA/TBP/DNA complex

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Abstract
The X-ray crystal structure of the transcription factor IIA (TFIIA)in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 Å resolution. TFIIA is composed of a β-barrel and a four-helix bundle motif that together have a boot-like appearance. The β-barrel extends the TBP β-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.