TFIIIA and homologous gens. The ‘finger’ protiens
Open Access
- 1 January 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 14 (11) , 4385-4391
- https://doi.org/10.1093/nar/14.11.4385
Abstract
Differential regulation of gene expression , in a precise temporal and spatial pattern during development, is thought to be partly mediated by site specific DNA binding proteins which promote a selective activation of gene transcription (I). From studies on Xenopas TFIIIA, a factor selectively required for transcription of 5 S ribosomal RNA genes. Miller et al. (2) proposed a novel structural model of interaction between DNA and DNA binding protein. The striking homology of TFIIIA with several recently sequenced Drosophil and yeast gene products suggests that multiple regulatory proteins may have evolved from a small ancestral DNA binding protein domain and that the characteristic features of TFIIIA and TFIIIA-5S DNA interactions may be of general significance.Keywords
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