EXPERIMENTAL HYPERTENSION

1 June 1937

journal article
research article
Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)

Vol. 17 (6) , 1040-1054
https://doi.org/10.1001/archopht.1937.00850060096009

Abstract

This communication deals with the pathologic changes in the eyes of dogs with persistent elevation of the blood pressure produced by means of renal ischemia. At the time when the first report¹was made it was known only that permanent elevation of the systolic pressure resulted from this method. This fact has been confirmed by several publications,²but recently it was shown^2d,ethat there is also an elevation of the diastolic pressure in such animals. This report is restricted to a study of the abnormal changes detected ophthalmoscopically in eight dogs and one monkey with experimental hypertension for varying periods and to the pathologic changes in the eyes of one of these animals (dog 3-8 of the previous report¹). This is the only animal so far from which the eyes have been removed during life for a study of the microscopic changes.

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