Hydrogen bonding effects on 31P NMR shielding in the pyrophosphate group of NADPH bound to L. casei dihydrofolate reductase
- 7 October 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 291 (1) , 21-23
- https://doi.org/10.1016/0014-5793(91)81094-o
Abstract
A comparison of 31P NMR chemical shift data and X‐ray structural data [Filman, D.J., Bolin, J.T., Matthews, D.A. and Kraut, J. (1982) J. Biol. Chem. 257, 13663–13672] for complexes of NADPH with L. casei dihydrofolate reductase indicates that solvation effects play a major role in influencing the 31P shielding of the pyrophosphate nuclei whereas changes in P‐O‐C5‐H5' torsion angle have little effect.Keywords
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